Joe Kool,
I have no personal experience with other GNR calibers, but I can testify that a 41 GNR #2 throwing a 170 grain Sierra bullet out at 2,350 fps (and I load down three grains from Gary Reeder's suggested max loads) will absolutely devastate anything you shoot with it. The hydrostatic shock is tremendous and has to be seen to be believed. I haven't even bothered to work up loads based on 210 grain 41 caliber bullets having seen what happens with the Sierra 170's. My current 41 GNR #2 is a 13" Reeder barrel with his patented brake. I have a good friend who's eight year old son loves to shoot it since it's so tame with the brake.
The only thing I will do now as far as load development is increase the powder charge a grain at a time from 33.0 grains of W296 with Sierra 170's (safe in my gun only - use good and widely accepted load development practices, logic and good judgment for your own load development). I estimate that I will end up some where between 2,500 and 2,600 fps when I increase to Gary Reeder's published load data of 36.0 grains of W296 which is MAXIMUM in his test barrel. Do the math computations for both energy figures and the Taylor Knockdown Index (TKI), you will be amazed! The 41 GNR #2 delivers about 50" higher TKI than a 270 Winchester from my 13" barreled Contender! My current SS barrel is a real fire-breather the way it is in my Contender, but I am ordering a 15" SS Encore version of the 41 GNR #2 - I expect it to reach around 2,700 to 2,800 fps with Sierra 41 caliber 170's - that's what I call KNOCKDOWN!
I can highly recommend the 41 GNR #2 to you, but Gary Reeder also has the 410 GNR which is based on the 454 Casull case, which fits better into revolvers, as well as the 41 GNR which is the 44 Magnum case necked down to 41 caliber. Reeder told me that the 41 GNR #2 has the velocity advantage in the longer barrels over the 410 GNR by about 100 fps even though the case volumes are virtually the same (just different shapes).
I hope this information is helpful. Let me know if I can be of further assistance.
Javelina