Im not a fur hunter so I really dont care about anything except putting them down as quickly and humanely as possible.
Heres what works for me:
40g Nosler BT @ 4050fps, .22-250
52g Speer/Hornady BTHP @ 3578fps, .22-250
75g Hornady V-Max @ 3609fps, .257 Roberts
160g Barnes XLC @ 3020fps, 7mm Rem Mag
The 160g XLC really isnt well suited for coyote hunting because of their propensity to ricochet, but they were extremely effective on the two Ive taken with it. On one I never did find the entrance or exit wound and he dropped like a stone.
The 40g BT is an amazing effective bullet but inconsistent when it comes to damage. Sometimes there is only the tiny entrance, other times there is a softball sized exit.
The 52g Speer/Hornady BTHPs get used most often in my .222-50 because I got a bunch of both on the cheap. But when this batch is done Im going to the 50g V-Max.
The 75g V-Max is my favorite, partly because it is effective and partly because the 22 Ruger is so much easier to get in and out of the truck than the heavy-barrel 26 .22-250.
Speaking of which, the sun is up and its time to go looking for Wile E. ...