I wouldn't think twice about using the 85gr sierra for deer, my dad has a good friend who has used that bullet on 20+ michigan whitetails with great results. I have never had any problems with the sierra 100gr SBT or the Nosler 100gr Partition, I have had poor luck with 100gr coreloks and 100gr winchetser PP. I had a corelok pensil right thru a deer an a winchester PP blow up on the shoulder of a small doe, no blood or hare, was eventual found about 100 yards away. It was laying there with no appreciable damage, not a drop of blood. I imagine the 85gr TSX would also work very well.