It would be very easy to do, and a little mod to the ejector would do the trick. The standard twist rate for a 22-250 is 1 in 14 so the 1 in 12 would work with heavier bullets, probably up to 65gr or so. I had a 1 in 17 twist 22-250 that would shoot 45gr bullets perfectly. Different ejectors have different shaped shanks that go under the barrel, so not all will fit all others. Larry