Handi to a wild cat, one I personally would consider is the 257DGR. A very easy one does not need fire forming, cheap brass, almost as good as a 25-06. Made from 260Rem or 243 or 7mm08 or even 308. 100 gr bullet at 3300 or close to it. A 223 24" bull barrel would do it nicely.
Has a 30geg shoulder and a .300 long neck. Now there is a 25cal deer rifle with gusto and the 100 or 115gr TSX bullets.
I would rather have that caliber than the 257 Roberts, well I can always get another 25. Don't know where a guy get a reamer to rent. You could try the designer Duane Spooner in Tappen ND.
A low key retired Bench rest cartrige from 223 to 6mmx222Rem Mag. This is a super 300 yard varmint tack driver. No fire forming just expand the neck and go shooting.
The 25-284 would not work well in a Handi, because of the rebated rim.
The extractor or ejector would scrape on the case body?
? There is no advantage in that case in a Handi since it duplicates the 25-06.