i'm getting a 22-250 in a few days and i want to start loading for it. i've got 40, 50, and 55 grain V-max bullets bullets, and my powders on my bench are IMR 3031, IMR 4064 , bl-c2, varget and rl-15. the gun is for p-dog shooting (0-300yards) and targets so barrel life is something to think about (not to big of a deal you can always buy new) if the barrel lasted 1000 rounds i would be happy.