dunawayeric
You don't say for which rifle. There are differences in the rifles available (strength of action and rate of rifling twist) that will effect the choice. However, the "classic" Hornet load is 11.5 gr of IMR or H4227 with a 40 or 45 gr bullet. The Sierra 40 or 45 gr Hornet bullet (the .224 works fine in all bores) should serve you well. Using a small pistol primer (yes, that's correct, a small pistol primer) the velocities will be around 2650 fps. The Sierra will give the type of terminal performance you're looking for plus this is usually a very accurate Hornet load.
Larry Gibson