Not to stir up the ju-ju.....
jr meredith, I think you ought to go for a 257 Wetherby Mag myself, it will outperform the 25-06 and the 6.5 Remington. I don't know how you are going to deal with the streached frame, guess that'll be your problem. But even with the 6.5 Remington, you'll have a streached frame. Others have tried rechambers to 300 Win Mag only to get the streached frame they were told they would get. The 450 only operates at 42,000 psi , not 55,000-60,000 psi. It is the reduction of operating pressure that allows for the chambering of the 450 Marlin with it's .513 case head diameter.
Operating at the same 42,000 psi the 450 does, the 6.5 would hardly give velocities equal to the 257 Roberts, but people are free to do any damned fool thing they want.
After the last fiasco we went through over rechambers, it would stirike me that it would be wise to lock a thread on what is known to be an obviously unsafe rechamber such as this one would be. (rimless AI chambers should fall into that catagory as well so far as I'm concerned) It should contain a note of interest to the poster that such a rechamber would be more wisely done in an action of a stronger design than the Handi and leave it at that. Poster is free to get ticked off, leave, or follow the good advise as they see fit.
Not my intent to ruffle any feathers, just it is not senseable to entertain threads that can obvioulsy go nowhere. The proper answer is to this whole disscussion is "If you want a breakaction single shot in a 6.5 Remington Magnum, go get an Encore. The TC factory offers H&H based magnum chamberings and warrants their frame for use with such, NEF does not, and none of us here are qualified to question their judgement. However, with the ongoing demand there is for such chamberings, it would be a sure bet that NEF would chamebr H&H based magnums were it practical in in the SB2 frame"