I voted for the 44 mag. to answer your question. But I wouldn't use it for a carry gun, I'd use one of my 45's. I just finished doing my own reaserch before signing on and was going to ask for a more indepth technical reponse. Heres something to look at: 9mm 115fmj 1100fps 309,260;9mm 124 fmj 1050 fps 304,268;38spl 125 sjhp 850fps 201,183; 357mag 125 sjhp 1200fps 400,326; 40s&w 155sjhp 1000fps 344,301; 40s&w 180sjhp 900fps 324,295;44mag 240sjhp 1300fps 900,754; 45acp 230fmj 800fps 327,304. Ok, first is the caliber, then the bullet weight and type, muzzel velocity(since I reload Igave the accurate velocities I use and would expect from other calibers, I don't have a 9mm or 40 s&w), the next two sets of numbers are the muzzel energy and the energy at 50yds(reasonable distance for comparison). It may look confusing, but clearly the 44 has the most energy and a sjhp will spend most of it in your target. Hey, have you ever shot a bowling pin off a table with a 357, 45 or a 44? Lots of fun and I'll tell you the 44 cleans em off as if you hit it with a baseball bat! I think the 357 tecknically comes in second, then the 45, but the 45 is mmf. I'd make it my second choice. Which brings me to my question to law enforcement and anyone else interested in the technical stuff. What is the minimum energy given for takeing out a target at close distances? I've only found info on deer and other big game. They say 900 ft-# is the minimum for taking deer size game, a buddy told me 750 ft-#. A little help in this issue would be appreciated.