Ruger does adjust to point of aim if you send it to them, some send in a target with the gun. But Ruger will adjust.
I pesonally don't like a six gun with fixed sights that shoots off to one side, so I'll do what it takes to get it straight. As far as single actions go, if they are shooting left, the gun maker, or smith can turn the barrel in just a very slight bit to get the POI to come back to the right. There usually is enough cylinder barrel gap to do this, but if there is not, you'll need a smith or the manufacturer to perform the extra work, unless your a pretty handy.
Read ion this sight where someone sent their Ruger in, and they said they got it back shooting dead nut POI with standard loads.
Squeez your shots off ever so slowly, so slow you surprise yourself when it goes off, using a bit of a rest, you'll see where she shoots when you sqeeze em off nice and slow. that would be where the gun shoots if you do your part. I don't jam the gun into a sandbag either, I support my hands and wrists a bit, but leave the gun butt and barrel free. That's just me, not saying I know much, but I've seen guys jam the butts of their guns into sand bags and wonder why it shoots so far off. Well, a single action in your hands bucks a certain way during recoil. Not an expert here, just what I've read about and observed at the range.
Shooting off hand, especially with one hand...if your Ruger shoots in a different spot than where it was when you were being careful, it's just your habbits. Like pulling it instead of squeezing it.
Anyways...if you figure it shoots to the left with carefully squeezed off shots, your probably right, and I'd send it to Ruger and get it shooting where standard loads shoot. You'll be a lot happier in the end.
Sheesh...so I ramble on or what???