I've had 1 243 rifle for close to 25 years now and have killed more deer with it than I can count. The vast majority of them have been killed with a 100gr bullet,whether it was a Hornady PSP or RN, Sierra Gameking or Corlokt didn't seem to matter. Before coming onto the 100 gr bullets,I had used 85-87 gr SPs. Choices in powder varied.
As stated by others here, I've had the BANG-FLOP effects and I've had some that took a while to find. Recently I shot a buck and got the Flop. When the does, that he'd been with, stopped,I picked out one and toched off another shot. She ran about 75 yds. Same sort of shot, close to the same placement.
I shot a doe this year with a 12ga slug and she ran about 80yds,slinging blood all over the place. She had a hole on one side(the exit side) that you could stick your fist in! There's just no telling what's gonna happen when you pull the trigger on an animal.
If you're going to be hunting some larger deer,stick to the heavier bullets, whether they're the "premiums" or not. I believe the varmit weight bullets are just asking for problems with lost animals.
HWD