I grew up in South Texas shooting lots of whitetails, average shot 150 yards
all were shot with a 243 that belonged to my dad
he killed a TON of deer and he reports only 1 ever lost with a 22-250
99% were shot through the neck and they dropped in there tracks
That's how dad did it (and my uncles) and so that's how I did it.
I bought my own deer rifle a few years ago, found an old sako L57 Forrester 243 at a gun show and grabbed it.
My dad told me that I had been shooting 85g BTHPs all those years, that gun was a tack driver and I never even thought about the distance... just zeroed in on the neck (maybe towards up a bit if it was "way out there"), steady, breathe exhale slowly, squeeze and surprise! the gun went off and I watched the deer drop through the scope (or flip up and back, whatever)
I bought some federal premiums with the same bullet and they wouldn't group worth a damn
Winchester 100g sps 3 shot groups could be covered by a quarter easily, sometimes touching each other
I shot a nice buck 2 years ago with it loaded with Winchester 95g Ballistic Silvertips, neck shot at about 130yards, drop
Being that I hunt out of a stand most of the time and that I go for neck shots (never ever shot at a deer that was walking away, just doesn't happen in the places I have hunted, most of the time it's a broadside shot or walking towards me) I have always subsribed to the light fast and flat theory (probably because my dad has an old sako 22-250 that has killed a TON of deer since it was built in 1965 and he always did neck shots)
Yesterday I took a box of Fed 80g softpoints, I got a 3 shot, one ragged hole grouping at a hundred yards.
If one of those hits a deer in the neck from just about any angle he ain't going anywhere...