A few suggestions as I have 'been there - done that' too many times.
I always shoot 5 shot groups. No matter how good you try, you can get a flyer or shot that just doesn't do what it is supposed to.
I always shoot at LEAST 2 groups of 5 of each load. So I have 10 rounds with same bullet, powder/weight, primer.
When using rifle casings that take that much slow burning powder, my increments are in .5 grains.
Your scope is a little canted, but that wont make any difference if you use exactly the same sight picture. For this exact reason, majority of my targets have dark squares and/or lines that I can use to 'square up' my cross hairs. With same sight picture, even if scope canted, they should all hit same place.
When I shoot my groups, I alway load one, yes one, round at a time, and let the bolt pull the round out of the magazine. If lever action, it goes into magazine also and the action still chambers the round. May sound silly, but put a few 220 grain -06 rounds into a magazine and you will change your impact point at longer distances.
Have fun with your project. If 4350 doesn't get you there, try H4831. It is one of the more popular .243 powders.
Steve