Yep, it works. I used to shoot Lee 350gr. 45-70 bullets out of my Vaquero over a bunch of 2400. If they're sized to fit the throats they usually shoot quite well, in my case they were about 3 feet high at 25 yards but dead on at 200. I had fun giving the rifle shooters fits at our range by ringing the 200 yard gongs with my little pocket pistol.