Reloading the .45 ACP can seem mysterious until you learn a few tricks.
Here's what has worked for me for over 30 years of competition shooting:
1. Do NOT trim cases! Even in a match conditioned pistol, trimmed cases contribute little to better accuracy. Headspace issues develop when you mix trimmed with untrimmed cases. Instead, keep your cases segregated by number of times fired when starting out with new cases.
2. Use a pistol-sized powder measure for greater consistancy. Rifle-type measures loose consistancy when used for small pistol charges.
3. Use medium-weight (200-230 grain) hard cast or copper-plated bullets. The .45 ACP has shallow rifling, and hard-cast bullets give better accuracy.
4. Avoid hotrodding this caliber. The standard M1911 design does not do well with maximum pressures or heavy bullets (+230 grains), and gun life is greatly shortened if you insist on using hot ammunition.
5. Use a taper crimp, not the conventional roll crimp for revolver ammunition. If you don't have a taper crimp yet, set your crimp die to just barely straighten out the case mouth flare. Use your sizing die (set shallow) to make sure the case mouth is straightened out. Use a spare .45 ACP barrel as a gage to make sure your loaded ammo chambers easily.
6. OAL is touchy for this caliber. Even a few thousandths over max can give magazine jams or stoppages.
7. Standardize your loads for performance and economy. I've settled on just two loads for 98% of my shooting: 200 LSWC at 800 fps target loads, and 230 RNL to duplicate factory ball.