Actully there was a study a few years back where it was proved that the type bullet and shot placement was more of an issue than caliber...Most of the deer I've killed with a .243 dropped at the shot....none went over 125 yards...If she loses one...it won't be because of caliber....
We kill 45-50 deer a year on our farms...I have seen them shot and shot them with 22-250, .243, .260, 7mm-08, .270,.280,.30-06,.270WSM, 7mm Mag,.300 Win Mag, 30-30 and of course, slugs, buckshot, 50 caliber inlines and .40, .45 and .54 caliber round balls...Once you get into the high powered rifles from .243 to 300 Mag...it dosen't matter...Actually with the larger caliber, you are blowing most of that energy into the ground on the off side of the deer...
You certainly don't need more than a .270 or a 7mm-08.
I don't advise a .260 or a 25-06...I had to take a fellow on a 60 some mile round trip a few years back trying to find a box of .260 rounds...If you reload, its ok...As long as you take an extra box, in case you fall in the swamp and knock your scope off like he did....And 25-06s have too long a barrel for what they are...I'd opt up for a .270 before a 25-06.
Nothing wrong with a 7mm-08...except they aren't popular everywhere and a .270 or .243 shoots flatter....They are nice in the Model 7....but I'm 6ft 5...and a Model 7 feels like a toy to me...And the blast with a 20 inch barrel is awful...