Frosty, it sounds like you're leaning towards the 10mm, and I think you'd be happier with it, just for the fact that it's a little different. The Ten is more flexible, useable bullet weights range from 135 to 200 grains, heavy stuff is good for deer and piggies if you want to hunt them with a pistol, and the 135's are outstanding manstoppers without the attendant overpenetration that gives the heavies a bad name. 45ACP ball overpenetrates human targets about 65% of the time, based on what I've read and seen, the hollowpoints are better but still not foolproof. But the 135 and 155 HP rounds in the Ten have a good reputation for expanding well and stopping quickly.
I've owned 45's, and decided the 40 was more to my liking. The Ten is just more of a good thing. More bullets, better ballistics, more flexibility. And I also favor the Witness as a good semi-auto platform. I've had mine (in 40) since 1990, and it gobbles up everything I stuff into it. My son and I spent fifteen hours at the range this week over three days (he was on Spring Break and wanted to SHOOT!) and we put around 800 rounds thru my Witness without cleaning it. It never bobbled, stuttered, or choked. It's been that way for 16 years and 34,000 rounds, mostly pretty hot. I highly recommend it. But a Smith 610 would also be very cool!
Keep us posted.
Papajohn