I suppose that I can also add that I've been talking to a former Ruger employee about the new Vaquero. They kept the cylinder walls as thick as possible, just to be sure that those "Ruger Only" loads in all the manuals won't hurt the new Vaquero. Ruger is plenty aware of potential liability, and they kept the new Vaquero pretty darn tough.
The down side is, because of cylinder geometry, the new Vaquero can't be factory chambered in 44 WCF or 38 WCF, so don't bother asking Ruger. If maximum SAAMI size case rims are loaded into a New Vaquero in one of those calibers, the rims would overlap. YES, I know that virtually any production case will actually fit. Custom new Vaqueros have already been rechambered, successfully, for the WCF rounds. However, Ruger is not willing to make a gun that "almost always works with almost all factory rounds." It's 100%, or nothing. Can't really say I blame them.
Anyway, I'd limit those New Vaqueros loads to between Colt and the old "Ruger Only" loads, as a working maximum. Or, play it safe, and stick with Colt level loads. If you can't knock it down with a 255 grain bullet going 900 fps, you shouldn't have picked a fight with it, anyway!
