in a word, yes, but you will get a ton of responses that will range from yes to hell no, and all by people that haven't done it. answer,...... it's been done before and many times at that. lynn thompson from cold steel has stopped a couple with his FA454. anyway, the bottom line on a charge, and this is the part where you can tell who's done it and who hasn't, is if you want to stop a wounded buffalo you gotta penetrate the CNS. as in, central nervous system. you're not gonna turn a buff charge. any gun capable of penetrating the skull of the buff is capable of stopping the charge, and no gun will top a buff to the body. check out mark sullivan's videos. he stops his charges with one shot right to the brain, blammo. a couple aren't right on the brain but the animal is dazed, goes down, and he takes it in the brain right after, but that's using a heavy .600 nitro.
one particularly notable charge from his videos are one of the hippo charges where his client hits it just below the brain with a 416 rigby i believe and it doesn't slow it down one little bit until sullivan stops it with one of his smaller doubles with a perfect brain shot at about 5 yards or so. watch the final one on black death where he hits the buff in the head with a big double and the buff doesn't do a thing and keeps coming. the second one brains it and it falls where his feet were after he jumps out of the way of the falling buff.
bottom line, brain shot..........stop charge. no brain shot............no charge stopped.
he's got a new video which will answer your questions about anatomy and he breaks down the shots on all his charges and points out how most everything you've read is wrong and backs it with unquestionable proof.
that said......after reading and watching his stuff i've come to learn most of the top gun writers are just pretty much full of it and obviously didn't do and stop the charges they claimed.
those videos and some of the stuff i've gotten to read about those that have "been there" and done that is that, a pistol will do it.....44 mag with garrett's, 454, 500 smith, period will all do it if you hit the right spot. if you don't and hit to the body or miss the brain, none will do it.
besides a big double you can shoot really well, i truly believe the best gun for close quarters dangerous game is a wild west copilot leveraction chambered in .45/70 or better yet, the .500 alaskan.