Don't know about 4350 from experience, but for my Browning 1886 with 400gr gas checked bullets, of 2495, 5744, RL7, 3031, H322, 4198 and Varget, by a wide margin, Varget was best followed by 3031. The others were quite a distance behind. Velocities of about 1600fps are possible while staying within trapdoor pressure ranges. With a straight case, I believe 4350 to be far too slow and normally would not even think of trying it. BOL.