Forget about those too slow powders for the 45-70.
Here is an example of the range of powders that should be considered for use in the 45-70:
80. N130 (Vihtavuori)
81. SP-3 (Vectan)
82. 680 (Winchester)
83. N200 (Norma)
84. 1680 (Accurate)
85. AR2207 (ADI)
86. H4198 (Hodgdon)
87. N133 (Vihtavuori)
88. 4198 (IMR)
89. BM1 (ADI)
90. Brig 4197 (Scot)
91. 2015 XMR (Accurate)
92. Brig 3032 (Scot)
93. Reloader 7 (Alliant)
94. 3031 (IMR)
95. Benchmark (Hodgdon)
96. BM2 (ADI)
97. N201 (Norma)
98. Brig 322 (Scot)
99. AR2219 (ADI)
100. H322 (Hodgdon)
101. X-Terminator (Ramshot)
102. 2230 (Accurate)
103. 748 (Winchester)
104. Reloader 10X (Alliant)
105. BLC-2 (Hodgdon)
106. AR2206 (ADI)
107. 2460 (Accurate)
108. H335 (Hodgdon)
109. TAC (Ramshot)
110. H4895 (Hodgdon)
111. 2495 XMR (Accurate)
112. AR2206H (ADI)
113. Reloader 12 (Alliant)
114. 4895 (IMR)
115. Brig 4065 (Scot)
116. N135 (Vihtavuori)
117. Varget (Hodgdon)
118. 5000 (Vectan)
119. AR2208 (ADI)
120. 4064 (IMR)
Even IMR 4320 is to slow for optimal loads, particularly with barrels 26" or shorter.
For a 300 grain bullet I use the following load which would be equally suited to your H&R:
Marlin 1895 45-70 22" barrel
300 grain Sierra (2.525" COAL), Hornady (2.55" COAL) or Speer (2.53" COAL)
Winchester brass, 2.1" trim, if necessary
CCI 200 primer
55 grains H4198
2180 fps with the Hornady