Welcome aboard, Jason!!
I have only used XMP5744 in my .45-120 BC with my cast loads, but I have some SR4759 that I haven't tried, it's supposed to be the cats meow for reduced loads, although the 5744 works great. All data that I've read from Accurate and Hodgdon says
not to use fillers, so I haven't, hasn't been a problem even with 50% case density in the big .45-120 case which is considerably bigger than a .45-70 case.
The only 405gr bullets I've shot are the rem jacketed and Cast Performance WFNGC. My preference has been for the 525gr Beartooth Piledriver, but the only thing I've killed with it is paper!! Down the page is a thread by Grizz and a link to his penetration test thru a dozen water bottles with this bullet!!
Tim