For primers, I'd start with Fed 215. This is what Weatherby uses on their factory ammo. In my 257 Weatherby Mark V, I had the best luck with Sierra 117 grain gamekings and H4831SC. Didn't get consistent results with 100 grain bullets and different powders, however, W760 with Speer 100 grain spitzers showed some promise. Tried a few different bullets with Accurate Arms 8700 powder and nothing short worth a darn. Loaded up a couple different bullets recently with IMR 7828 but haven't shot them yet. But I have high hopes (my local shop didn't have the 7828SC).
Of course, your results may differ.
Good luck, and good shootin'.