Last year I watched my hunting partner shoot severial coyotes with his .17, I saw a few get up that had to take another bullet. My hunting partner is not new to the game, he usually shoots a 250. He just wanted to use his .17 to see how it worked. I believe he told me he was using factory 25 gr bullets.
Let me add this, I shot my new rifle last year, I never seen any animal move after it was shot. I didn't kill alot of animals last year, maybe 40 to 45 coyotes. But nothing moved after being hit with the 64 gr 223 WSSM and it didn't make a mess.