I don't see why you can't. In fact with the rim design & the case being
slightly smaller in front of the rim than the 22-250 & the case being longer, it may work a little better than the 22-250 in the Handi, although I
have no way to prove that. I love the round, I used one on a bunch of
Varmits back in the 70's(Ruger 77 Varmit). About the only thing I don't
like about the case is that it has to be trimmed alot. But, if you neck or partial size & load to upper end 22-250 performance (seems that handi's group better at normal pressures anyway), it should do great.
I almost wish you had not brought this up. I got to thinking & the new
24" fluted barrel would make a fine conversion. It is hard to get a Swift in
factory form with a 1-9 twist, but with this barrel you would have one & you would have a 22centerfire firing heavy bullets like the 77mk with 6mm wind bucking. I guess that I could send one of those barrels to Mr. York for re-chambering about the same time that I send a 25-06 for the 338-06 job. Thanks Mr. Stimpylu32 for showing me how to spend more money!