I would say 'Yes', unless both your Ruger and your 45 are scoped. I recall shooting scoped contenders and it was, for me, not easy. I found I had to hold real still, as in very still, to get the scope on target and ready for the gun to shoot. I also recall trigger squeeze was very important with those single shots due to (my) wavering all over the target. I finally got to the point where I could hit unshot (whole round ones) clay pigeons on a 100 yd berm with a 30 Herret Contender but it was not my favorite sporting effort.
I can pick up open sight pictures on my pistols pretty quickly but scopes out to arms reach are tricky, at least for me and that might be a technique adjustment you might have to consider.
Good target practices always help. Proper grip, proper stance, proper breathing, proper sight alignment and, proper trigger squeeze are all important factors in any handgun hunting endeavour. In that regard it is the same as targeting or hunting with either your 22 or your 45. The single shot pistols are heavier and the trigger pull may not be familiar to you, but we all recommend practice, practice and lots more practice. And good luck handgun huntin'. Mikey.