There is a huge difference in the 45ACP and a light loaded 45 Colt on game. My best loads for the ACP were with 225gr TC from Laser Cast loaded fairly warm out of a Longslide Wilson Classic. It had as wide a nose as I think will feed 100% of the time. It would kill deer, but what want if it goes threw both lungs, just not alot of knock down power. Shot alot of hogs with it also, and all died, just not like Thor's hammer hit them. A light 45 Colt on the other hand, the before mentioned 255SWC, or better yet the 265 Cast Performance, or even better the 280gr Beartooth, loaded at 850-950fps, will thrash a deer/black bear/wild pig, and has little muzzle jump and blast, maybe less than the 45ACP loaded hot out of a 1911. It also does better on rocks, mud, wet paper, and trees. When marlin came out with the long barreled cowboy 45LC, I loaded it light and lighter, and lighter, with the 265 cast performance bullet and got the noise level down to near a 22LR, so I could play with it in the yard, I live in a rural area. I shot several deer with it, broadside, behind the shoulder, all between 30-60 yards, and all bullets exited, the longest blood trail was 70 yards, the shortest was about 3 jumps.