I picked up a box a few years ago after purchasing a new Marlin with the "Ballard" rifleing. I shot only one deer with the load-an average sized doe. Unfortunately, I was too close (less than 50'). In my haste, I missed tucking the shot behind the shoulder and got the shoulder instead. My poor marksmanship combined with the rather soft slug and close range ruined a great deal of venison. I concluded that for my purposes (mostly "woods hunting" with average shots less than 50 yards) the Remington 300 is just too soft. (Then again, if I hadn't botched the shot (hitting the shoulder) the round may not have acted like an RPG.)
That's only one experience with one deer. Perhaps others can shed a more positive light. (On the plus side, the load has mild recoil and very good accuracy with my Marlin).