Geez, what a war on words. I can provide some first hand experience for you on the S&W 45 LC and its capabilities. I've hunted with that gun for a few years. The Performance Center 45LC 629-5 is a strong gun. When I first bought the piece, I called SW tech support to inquire as to what level the gun could be loaded. The answer in a nutshell was "hot, but not super hot". I balanced that advice with an article by Linebaugh and decided to shoot rounds in the 1200fps range. I haven't tested it loaded real hot, but I've been shooting beartooth bullets 280gr WFNGC at 1250 fps for several years...and here's what I can tell you about that aspect of your question: 1. It's the kiss of death on whitetail out to easily 75 yards. The last one I shot was at about that distance and she fell like a stone. 2. I have both a .41 and a .45 - either will perform well on whitetail, so it's your choice. Both have limited factory offerings, but adequate - Winchester makes a hunting load for the 45 and the 41 (the latter is a Supreme 240 gr platinum tip, I believe the 45 loading is a 250 grainer.
The 45LC SW Performance Center gun I have outshot my FA 454. It's a one hole gun. Doesn't mean your will be, but I have (4) PC guns now and all have shot very well.