Many will say yes, and I would have to agree...BUT I find loading them to an intermeadate velocity level works best for me.
In my case, I have the Marlin, Ruger#1 and a Browning 1895 to send those heavy weight projectiles at high end velocities.
The Handi is a leight weight "handi" rifle. While I am not recoil shy, its gets ornery at top velocities.
I like 15-1600 W a 400gr procectile.
JMHO,
CW