H110, as noted previously, has it's peculiarities. The recommended charges for it in all calibers for which it is appropriate cannot be reduced more than a few percent (please check out Hodgdon's site on this) before ignition failures and partial ignitions are encoiuntered. When this occurs, the bullet can and often is pushed out of the case, into the barrel but lodges there creating an obstruction that may go undetected. The extracted case will give the appearance of having been fired. And, of course, if another round is inserted into the chamber and does happen to fire, then it's very likely that the gun will explode and there also may well be injury to the shooter.
H110 demands a full case and often a compressed charge to give reliable ignition. It is appropriate only for straight walled magnum type handgun calibers and a few of the smaller case capacity .22 calibers (ie .22 Hornet and close cousins. It is most definitely unsuitable for the .45-70 and should not/never be considered as an option for this caliber. This is one instance in which the powder burn rate, entered iinto a software program or mathmatical calculation will give completely misleading data, creating a set up for disaster if followed.
Best Regards,
stuffit