I've had at least one Security Six in my collection for the last 30 years. My current Security Six is a 4" stainless from the mid-'70s, pre-warning but post changes to the grip frame. I picked it up a couple years ago in pretty rough shape, cleaned it up, changed the springs, polished the sear/trigger, put a Millett rear on it, and replaced the grips with a Hogue Monogrip. The end result is that this is probably the best shooting and smoothest Security Six I have ever owned. I carry it frequently and I put at least 250 rounds a month through it.
Here's where I'm heading with this. I just bought a new SP101 and I recently fondled a new 44 Alaskan (I am ready to trade my first-born for it). One thing I noticed about these new revolvers is how much tighter they are than my older 357 Security Six. There is almost no forward-and-aft or lateral movement of the cylinder. It locks in place and the barrel-cylinder gap is noticeably less than on my SS.
My Security Six, on the other hand,. has enough play in it that the barrel-cylinder gap goes from .002"-.007" when I push or pull on the cyinder. It normally rests at .003". Though there is a little lateral play when the cylinder is locked in place, the alignment on all cylinder chambers appears good and I get zero lead shavings. Also, the forcing cone seems to be in great shape.
This revolver does everything I expect it to do and like every Security Six (3 total) that I've ever owned, it does everything well. So should I care that it's a little loose? I intend to hang onto this revolver for a long time. Would I be well served to have a good Smith go over it and at least get rid of the cylinder shake and tighten up the barrel-cylinder gap?